"Considered from the wider aspect, in breeding the honey bee we are confronted by a series of problems not met with in the breeding of live-stock and plants We have constantly to bear in mind the influence of parthenogenesis, multiple mating and the extreme susceptibility of the honey bee to inbreeding. Indeed, inbreeding is the primary limiting factor whenever an intensification of a resistance to any particular disease is at issue."
Brother ADAM
(American Bee Journal 131(8) 1991)